Monday, 3 February 2014

Autistic Brains Create 42 Percent More Information During Rest



New research from Case Western Reserve University and University of Toronto neuroscientists finds that the brains of autistic children generate more information at rest -- a 42% increase on average. The study offers a scientific explanation for the most typical characteristic of autism -- withdrawal into one's own inner world. The excess production of information may explain a child's detachment from their environment.




Published at the end of December in Frontiers in Neuroinformatics, this study is a follow-up to the authors' prior finding that brain connections are different in autistic children. This paper determined that the differences account for the increased complexity within their brains.
"Our results suggest that autistic children are not interested in social interactions because their brains generate more information at rest, which we interpret as more introspection in line with early descriptions of the disorder," said Roberto Fernández Galán, PhD, senior author and associate professor of neurosciences at Case Western Reserve School of Medicine.

The authors quantified information as engineers normally do but instead of applying it to signals in electronic devices, they applied it to brain activity recorded with magnetoencephalography (MEG). They showed that autistic children's brains at rest generate more information than non-autistic children. This may explain their lack of interest in external stimuli, including interactions with other people.

The researchers also quantified interactions between brain regions, i.e., the brain's functional connectivity, and determined the inputs to the brain in the resting state allowing them to interpret the children's introspection level.

"This is a novel interpretation because it is a different attempt to understand the children's cognition by analyzing their brain activity," said José L. Pérez Velázquez, PhD, first author and professor of neuroscience at University of Toronto Institute of Medical Science and Department of Pediatrics, Brain and Behavior Center. "Measuring cognitive processes is not trivial; yet, our findings indicate that this can be done to some extent with well-established mathematical tools from physics and engineering."

This study provides quantitative support for the relatively new "Intense World Theory" of autism proposed by neuroscientists Henry and Kamila Markram of the Brain Mind Institute in Switzerland, which describes the disorder as the result of hyper-functioning neural circuitry, leading to a state of over-arousal. More generally, the work of Galán and Pérez Velázquez is an initial step in the investigation of how information generation in the brain relates to cognitive/psychological traits and will begin to frame neurophysiological data into psychological aspects. The team now aims to apply a similar approach to patients with schizophrenia.



A new study published in the journal Frontiers in Neuroinformatics shows that autistic brains can create 42 percent more information on average while at rest.
The research, performed by Case Western Reserve University and University of Toronto neuroscientists, could explain an autistic child’s detachment from his/her environment.
“Our results suggest that autistic children are not interested in social interactions because their brains generate more information at rest, which we interpret as more introspection in line with early descriptions of the disorder,” Roberto Fernández Galán, PhD, senior author and associate professor of neurosciences at Case Western Reserve School of Medicine, said in a statement.
Researchers used magnetoencephalography (MEG) to record brain activity of autistic children, revealing that their brains at rest generate more information than non-autistic children. They also quantified interactions between brain regions and determined the inputs to the brain in the resting state allowed them to interpret the children’s introspection level. The team believes this finding could explain an autistic child’s lack of interest in external stimuli, such as interactions with other people.
“This is a novel interpretation because it is a different attempt to understand the children’s cognition by analyzing their brain activity,” José L. Pérez Velázquez, PhD, first author and professor of neuroscience at University of Toronto Institute of Medical Science and Department of Pediatrics, Brain and Behavior Center, said in a statement. “Measuring cognitive processes is not trivial; yet, our findings indicate that this can be done to some extent with well-established mathematical tools from physics and engineering.”
This study is a follow-up to a previous finding by the same team in which they were able to develop a method to help detect autism in children. The team used MEGs and analyzed dynamic patterns in brain activity to determine the brain’s functional connectivity, which is the communication from one region to another. They were able to detect autism spectrum disorder with 94 percent accuracy using this method.
“We asked the question, ‘Can you distinguish an autistic brain from a non-autistic brain simply by looking at the patterns of neural activity?’ and indeed, you can,” Galán said about the April 2013 study. “This discovery opens the door to quantitative tools that complement the existing diagnostic tools for autism based on behavioral tests.”

Read more at http://www.redorbit.com/news/health/1113060546/autistic-brains-more-active-during-rest-013114/#sPjyaJfcsyV6t31A.99
A new study published in the journal Frontiers in Neuroinformatics shows that autistic brains can create 42 percent more information on average while at rest.
The research, performed by Case Western Reserve University and University of Toronto neuroscientists, could explain an autistic child’s detachment from his/her environment.
“Our results suggest that autistic children are not interested in social interactions because their brains generate more information at rest, which we interpret as more introspection in line with early descriptions of the disorder,” Roberto Fernández Galán, PhD, senior author and associate professor of neurosciences at Case Western Reserve School of Medicine, said in a statement.
Researchers used magnetoencephalography (MEG) to record brain activity of autistic children, revealing that their brains at rest generate more information than non-autistic children. They also quantified interactions between brain regions and determined the inputs to the brain in the resting state allowed them to interpret the children’s introspection level. The team believes this finding could explain an autistic child’s lack of interest in external stimuli, such as interactions with other people.
“This is a novel interpretation because it is a different attempt to understand the children’s cognition by analyzing their brain activity,” José L. Pérez Velázquez, PhD, first author and professor of neuroscience at University of Toronto Institute of Medical Science and Department of Pediatrics, Brain and Behavior Center, said in a statement. “Measuring cognitive processes is not trivial; yet, our findings indicate that this can be done to some extent with well-established mathematical tools from physics and engineering.”
This study is a follow-up to a previous finding by the same team in which they were able to develop a method to help detect autism in children. The team used MEGs and analyzed dynamic patterns in brain activity to determine the brain’s functional connectivity, which is the communication from one region to another. They were able to detect autism spectrum disorder with 94 percent accuracy using this method.
“We asked the question, ‘Can you distinguish an autistic brain from a non-autistic brain simply by looking at the patterns of neural activity?’ and indeed, you can,” Galán said about the April 2013 study. “This discovery opens the door to quantitative tools that complement the existing diagnostic tools for autism based on behavioral tests.”

Read more at http://www.redorbit.com/news/health/1113060546/autistic-brains-more-active-during-rest-013114/#sPjyaJfcsyV6t31A.99